Top 20 Xiidra alternatives

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In 2025, the US offers diverse alternatives to Xiidra for dry eye disease management, including Signal12's Pro-ocularâ„¢, harnessing advanced delivery systems in Greenwich, and Olympic Ophthalmics' iTEAR100 neuromodulation device from Issaquah. Firms like Inoculus Ventures in Raleigh advance laboratory diagnostics, while Summit Eye Center in Lee's Summit delivers tailored surgeries. Across California, entities like East Bay Eye Center and Beach Eye Medical Group excel in vision health. These companies uniquely address dry eye with proprietary solutions, cutting-edge diagnostics, and patient-focused care.

Signal12 logo

Signal12

🇺🇸 Greenwich, CT, US

Signal12 is a clinical-stage biopharmaceutical firm specializing in innovative drug therapies for Dry Eye Disease, notably through its proprietary topical treatment, Pro-ocularâ„¢, which employs a unique transappendageal delivery system and targets the ophthalmic branch of the trigeminal nerve.

pharmaceutical
manufacturing
clinical-stage
biopharmaceutical
drug therapies
dry eye
ophthalmic
transappendageal delivery
trigeminal nerve
clinical studies
drug delivery
Company size: 11-50
Olympic Ophthalmics logo

Olympic Ophthalmics

🇺🇸 1065 12th Ave NW Issaquah, Washington 98027, US

Olympic Ophthalmics specializes in medical equipment manufacturing, focusing on innovative drug-free home-health solutions for ocular diseases. Their flagship product, the iTEAR100, utilizes neuromodulation technology to enhance natural tear production, addressing significant unmet needs in eye care.

medical devices
ophthalmology
neuromodulation
ocular diseases
home health
tear production
FDA clearance
therapeutic devices
energy-based technology
parasympathetic pathway
Company size: 2-10
Founded: 2017
Inoculus Ventures logo

Inoculus Ventures

🇺🇸 Raleigh, NC 27612, US

Inoculus Ventures specializes in developing innovative treatments for dry eye disease within the medical and diagnostic laboratories industry. Their focus on novel therapeutic solutions positions them as a key player in addressing this prevalent condition.

medical laboratories
diagnostics
treatments
dry eye
ophthalmology
healthcare innovation
Company size: 2-10
Summit Eye Center logo

Summit Eye Center

🇺🇸 1621 NW Blue Pkwy Lees Summit, Missouri 64086, US

Summit Eye Center is a comprehensive ophthalmology practice specializing in cataract surgery, glaucoma treatment, and dry eye disease management, employing innovative, minimally invasive techniques and a tailored approach to patient care. The focus on advanced lens implant options and a wide range of treatments in a welcoming environment sets it apart in the medical practices industry.

ophthalmology
cataract
glaucoma
dry eye
eye care
surgical options
lens implants
minimally invasive
treatments
patient management
vision health
Company size: 11-50
Founded: 2005
Cathedral Eye Care logo

Cathedral Eye Care

🇺🇸 8787 N LOMBARD ST Portland, Oregon 97203, US

A full-service optometric practice specializing in comprehensive eye care, including ocular disease management and a wide range of eyewear solutions. Known for its proactive approach to eye health, it offers innovative treatments such as specialty contact lenses and personalized care for various ocular conditions.

optometry
eye care
eye examinations
contact lenses
ocular disease
dry eye
sunglasses
pediatric care
orthokeratology
diabetic eye care
macular degeneration
glaucoma
Company size: 11-50
Founded: 2015
reVision Therapeutics, Inc. logo

reVision Therapeutics, Inc.

🇺🇸 Ridgewood, NJ 07450, US

ReVision Therapeutics focuses on developing innovative ophthalmic medicines by repurposing approved drugs and rescuing shelved therapies to address unmet needs in eye disorders. Their unique approach allows for faster and more cost-effective development of impactful treatments, including options for Stargardt disease and dry eye disease.

ophthalmic medicines
drug repurposing
retinal disease
Stargardt disease
dry eye
vitreoretinopathy
intravitreal delivery
therapeutic development
unmet needs
commercial potential
innovative therapies
Company size: 2-10
Founded: 2018
Alberta Eye Care logo

Alberta Eye Care

🇺🇸 2021 NE Alberta Street Portland, OR 97211, US

Alberta Eye Care offers a comprehensive range of optometric services, including eye examinations, contact lens fittings, and specialized treatments for various ocular conditions. With a proactive approach to eye health and a focus on innovative solutions like LipiFlow for dry eye management, it stands out in the retail optometry industry.

eye care
optometry
eye examinations
contact lenses
ocular disease
dry eye
glasses
sunglasses
pediatric eye care
glaucoma management
LASIK co-management
orthokeratology
Company size: 11-50
Founded: 2012
OcuSci Inc. logo

OcuSci Inc.

🇺🇸 Del Mar, CA 92014, US

Specializing in medical equipment manufacturing, OcuSci Inc. develops innovative products for the treatment of Dry Eye Disease, including the clinically proven MGrx Dry Eye Treatment System for in-clinic use and a best-in-class Dry Eye Compress that offers therapeutic moist-heat therapy. Their solutions provide rapid symptom relief and significant improvement within a month, addressing various related conditions effectively.

medical equipment
dry eye
ophthalmology
optometry
in-clinic treatment
home care
symptom relief
therapeutic compress
moist-heat therapy
macular degeneration
meibomian gland dysfunction
clinical products
Company size: 2-10
Founded: 2012
Primary Eye Care Associates logo

Primary Eye Care Associates

🇺🇸 5460 S Archer Ave Chicago, Illinois 60638, US

Specializing in advanced eye health and vision care, this optometry practice offers a range of services including LASIK, dry eye treatment, and orthokeratology, all delivered in a compassionate environment. With over 35 years of experience, it stands out for its commitment to innovative ophthalmic treatments and flexible appointment availability, including evenings, weekends, and 24/7 emergency care.

optometry
eye care
vision health
LASIK
dry eye
orthokeratology
ophthalmic treatment
emergency services
vision appointments
compassionate care
Company size: 11-50
Founded: 1996

HAZLETON EYE SPECIALISTS

🇺🇸 281 AIRPORT RD Hazleton, Pennsylvania 18202, us

Hazleton Eye Specialists offers comprehensive eye care services, including LASIK and cataract surgeries, as well as treatments for dry eye and glaucoma, positioning itself as a specialized provider in the healthcare sector focused on advanced ocular health solutions.

eye care
LASIK
cataract surgery
glaucoma treatment
dry eye treatment
Company size: 11-50
Eye Eco, Inc. logo

Eye Eco, Inc.

🇺🇸 40880 County Center Dr. Suite E & F Suite E & F

Eye Eco, Inc. is a medical device firm focused on developing innovative products and therapies that provide natural, long-lasting relief for dry, irritated eyes while promoting overall eye health. The organization emphasizes comfort and effectiveness in its offerings and actively contributes to charitable efforts aimed at curing chronic dry eye conditions.

medical device
dry eye
eye health
therapies
irritation relief
innovative products
chronic conditions
Sjogren's syndrome
Company size: 11-50
Founded: 2003
Bruder Healthcare logo

Bruder Healthcare

🇺🇸 1115 Ridgeland Pkwy 101

Bruder Healthcare specializes in the manufacturing of innovative medical equipment focused on ocular health and wellness, offering a range of therapeutic products for dry eye management and natural pain relief. Their patented technologies emphasize safety, efficacy, and convenience, making them a leader in the therapeutic eyecare industry.

medical equipment
therapeutic products
dry eye
pain relief
ocular health
analgesic products
eye compress
cold therapy
hygiene products
ophthalmic instruments
Company size: 11-50
Founded: 1986
Dry Eye Center of Alabama & Family Eye Care logo

Dry Eye Center of Alabama & Family Eye Care

🇺🇸 3490 Independence Drive Suite 110

Specializing in comprehensive eye care, this wellness and fitness service provider offers a wide range of treatments including dry eye management, pediatric eye exams, and advanced contact lens fittings. Their innovative approaches, such as Lipiflow and Intense Pulsed Light treatments, aim to deliver tailored solutions for both chronic and acute ocular conditions, ensuring clear and comfortable vision for all ages.

eye care
optometry
dry eye
pediatric eye care
scleral lenses
vision therapy
ocular diseases
contact lenses
Intense Pulsed Light
Lipiflow
eye exams
emergency care
Company size: 2-10
Founded: 2021
Animal Eye Center of New Jersey logo

Animal Eye Center of New Jersey

🇺🇸 48 Notch Road Little Falls, New Jersey 07424, US

Specializing in veterinary ophthalmology, this facility utilizes advanced equipment and gold-standard diagnostic methods to address a wide range of pets' eye care needs. With a board-certified veterinary ophthalmologist and a commitment to compassionate care, it offers tailored treatment plans for various ophthalmic disorders.

veterinary
ophthalmology
eye care
diagnostics
cataract
glaucoma
treatment
pet health
veterinary medicine
animal care
surgical evaluations
comprehensive exams
Company size: 2-10
Arena Eye Surgeons logo

Arena Eye Surgeons

🇺🇸 262 Neil Ave #320

Specializing in comprehensive eye care, this medical practice offers advanced services such as laser vision correction, cataract surgery, and LASIK, led by highly experienced, board-certified ophthalmologists. Recognized as a center of excellence, it is involved in clinical trials for new technologies and prioritizes exceptional patient care with a strong commitment to individualized attention.

eye care
LASIK
cataract surgery
laser correction
glaucoma
corneal transplantation
dry eye
goniotomy
scleral lenses
clinical trials
ophthalmology
Company size: 11-50
Founded: 1983
Thea Pharma US logo

Thea Pharma US

🇺🇸 303 Wyman St Suite 205

Specializing in ophthalmic pharmaceuticals, this organization is at the forefront of the preservative-free movement in eye care, offering a diverse portfolio of FDA-approved products aimed at enhancing eye health and treatment options. Its innovative approach focuses on delivering high-quality, preservative-free solutions to improve patient care in the U.S. market.

ophthalmology
eye care
pharmaceuticals
preservative-free
FDA-approved
eye health
optometry
treatment options
dry-eye drops
eyelid hygiene
patient care
Company size: 51-200
Founded: 2019

East Bay Eye Center

🇺🇸 5801 NORRIS CANYON RD San Ramon, California 94583, us

A multispecialty eye care practice specializing in comprehensive ophthalmic services across California, offering innovative solutions in vision health.

eye care
ophthalmology
multispecialty
vision services
eye health
healthcare
optometry
patient care
Company size: 11-50
ForSight VISION5 (now Allergan) logo

ForSight VISION5 (now Allergan)

🇺🇸 191 Jefferson Dr Menlo Park, CA 94025, US

ForSight VISION5 specializes in pharmaceutical manufacturing, focusing on innovative, non-invasive products that replace traditional eye drops for sustained therapy in treating major anterior segment eye diseases, such as glaucoma and dry eye. Its lead product, the Helios(TM) insert, offers a novel delivery system that ensures continuous medication administration for patients.

pharmaceutical
manufacturing
non-invasive
ocular
glaucoma
dry eye
allergy
sustained therapy
drug delivery
insert
Company size: 11-50
Founded: 2010
True Eye Experts logo

True Eye Experts

🇺🇸 19070 BRUCE B DOWNS BLVD Tampa, Florida 33647, US

True Eye Experts specializes in comprehensive eye care, offering thorough eye exams and innovative solutions for various vision needs, including pediatric care and specialized products for conditions like color blindness. Their focus on personalized service and advanced technology sets them apart in the medical practices industry.

eye care
optometry
eye exams
vision prescription
contact lenses
designer eyewear
pediatric eye
color blindness
dry eye
neurolens
MiSight
Company size: 51-200
Founded: 2010
Beach Eye Medical Group Inc logo

Beach Eye Medical Group Inc

🇺🇸 18582 Main Street Huntington Beach, CA 92648, US

Beach Eye Medical Group Inc specializes in ophthalmic eye care services, offering a comprehensive range of treatments including cataract surgery and laser vision correction. With over a century of combined experience, it stands out for its expertise in advanced eye care solutions.

ophthalmology
cataract
laser correction
LASIK
eye care
vision services
Company size: 11-50
Founded: 1985

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